Barry J Hoffer Selected Research

Glial Cell Line-Derived Neurotrophic Factor (GDNF)

9/2011	Is GDNF beneficial in Parkinson disease?
6/2006	Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study.
2/2005	Stroke and TGF-beta proteins: glial cell line-derived neurotrophic factor and bone morphogenetic protein.
1/2005	Transplantation of fetal kidney cells: neuroprotection and neuroregeneration.
1/2002	Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.

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Barry J Hoffer Research Topics

Disease

27	Parkinson Disease (Parkinson's Disease) 04/2024 - 01/2002
23	Traumatic Brain Injuries (Traumatic Brain Injury) 03/2023 - 09/2011
16	Neuroinflammatory Diseases 04/2024 - 01/2016
13	Stroke (Strokes) 04/2022 - 07/2002
10	Brain Injuries (Brain Injury) 03/2023 - 02/2009
9	Cognitive Dysfunction 11/2022 - 01/2013
9	Brain Concussion (Cerebral Concussion) 01/2020 - 10/2013
9	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2011
6	Type 2 Diabetes Mellitus (MODY) 04/2024 - 01/2009
6	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 01/2011
6	Inflammation (Inflammations) 03/2023 - 01/2017
6	Ischemia 01/2011 - 02/2003
4	Nervous System Diseases (Neurological Disorders) 03/2023 - 10/2018
4	Dyskinesias (Dyskinesia) 02/2023 - 08/2015
4	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/2022 - 07/2002
3	Wounds and Injuries (Trauma) 10/2021 - 02/2005
3	Gliosis 07/2021 - 03/2015
2	Mitochondrial Diseases (Mitochondrial Disease) 04/2024 - 11/2010
2	Ischemic Stroke 01/2020 - 01/2019
2	Craniocerebral Trauma (Head Injury) 01/2020 - 10/2018
2	Contusions 09/2019 - 01/2019
2	Brain Ischemia (Cerebral Ischemia) 01/2019 - 07/2002
2	Seizures (Absence Seizure) 02/2018 - 01/2016
2	Blast Injuries 01/2016 - 02/2014
2	Mental Disorders (Mental Disorder) 03/2012 - 08/2006
2	Huntington Disease (Huntington's Disease) 01/2011 - 11/2002
2	Parkinsonian Disorders (Parkinsonism) 01/2009 - 03/2007
2	Infarction (Infarctions) 03/2007 - 07/2002
1	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 04/2024
1	Neoplasms (Cancer) 04/2022
1	Disease Progression 04/2021
1	Hypokinesia (Bradykinesia) 01/2021
1	Obesity 01/2020
1	Brain Contusion 01/2020

Drug/Important Bio-Agent (IBA)

17	Dopamine (Intropin)FDA LinkGeneric 04/2024 - 08/2006
10	Proteins (Proteins, Gene)FDA Link 04/2024 - 07/2002
10	Exenatide (Byetta)FDA Link 01/2020 - 01/2013
8	Glucagon-Like Peptide-1 ReceptorIBA 04/2024 - 01/2009
7	Glucagon-Like Peptide 1 (GLP 1)IBA 03/2024 - 02/2014
6	pomalidomideIBA 04/2022 - 01/2016
5	Oxidopamine (6 Hydroxydopamine)IBA 04/2024 - 01/2005
5	CytokinesIBA 03/2023 - 01/2019
5	SynucleinsIBA 04/2022 - 01/2020
5	phenserineIBA 01/2020 - 01/2016
5	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 09/2011 - 01/2002
4	Thalidomide (Thalomid)FDA Link 03/2023 - 01/2019
4	Levodopa (L Dopa)FDA LinkGeneric 02/2023 - 08/2015
4	Glutamic Acid (Glutamate)FDA Link 01/2020 - 07/2002
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2009
3	IncretinsIBA 03/2024 - 10/2013
3	Neuroprotective AgentsIBA 01/2020 - 01/2019
3	pifithrinIBA 01/2020 - 05/2009
3	Peptides (Polypeptides)IBA 01/2020 - 01/2016
3	Messenger RNA (mRNA)IBA 01/2020 - 06/2006
3	3,6'-dithiothalidomideIBA 01/2019 - 09/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2005
3	Blood Glucose (Blood Sugar)IBA 01/2017 - 01/2009
3	Explosive Agents (Explosives)IBA 02/2014 - 12/2011
3	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 02/2009 - 01/2005
3	Transforming Growth Factor beta (TGF-beta)IBA 06/2006 - 01/2005
2	Cytochromes c (Cytochrome c)IBA 04/2024 - 06/2009
2	Sitagliptin Phosphate (Januvia)FDA Link 04/2024 - 03/2024
2	Amyloid (Amyloid Fibrils)IBA 11/2022 - 04/2021
2	AntioxidantsIBA 10/2021 - 10/2018
2	Immunomodulating AgentsIBA 07/2021 - 01/2020
2	ChemokinesIBA 01/2020 - 08/2009
2	tartaric acid (tartrate)FDA Link 01/2020 - 10/2019
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 09/2019 - 01/2016
2	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2019 - 02/2014
2	Nicotine FDA Link 10/2018 - 02/2018
2	Delayed-Action PreparationsIBA 09/2018 - 07/2018
2	Levetiracetam (Keppra)FDA LinkGeneric 02/2018 - 01/2016
2	Kainic Acid (Kainate)IBA 02/2018 - 01/2016
2	Cysteine (L-Cysteine)FDA Link 09/2017 - 01/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2015 - 09/2011
2	Mitochondrial DNA (mtDNA)IBA 10/2014 - 11/2010
2	NeurotoxinsIBA 02/2009 - 01/2005
2	Protein Isoforms (Isoforms)IBA 03/2007 - 06/2006
2	Nerve Growth Factors (Neurotrophins)IBA 01/2007 - 01/2002
2	Bone Morphogenetic Protein 7IBA 02/2005 - 02/2003
1	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 04/2024
1	Dipeptidyl-Peptidase IV InhibitorsIBA 04/2024
1	Protein Kinases (Protein Kinase)IBA 11/2023
1	ras ProteinsIBA 11/2023
1	LipopolysaccharidesIBA 03/2023
1	Transcription Factors (Transcription Factor)IBA 09/2022
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 09/2022
1	ImidesIBA 04/2022
1	Tetrabenazine (Nitoman)FDA Link 01/2022
1	phthalimidineIBA 04/2021
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2021
1	Glucagon (Glukagon)FDA Link 01/2020
1	Nerve AgentsIBA 01/2020
1	Annexin A5IBA 01/2020
1	BenserazideIBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020

Therapy/Procedure

3	Denervation 02/2023 - 03/2007
3	Therapeutics 04/2022 - 01/2011
1	Oral Administration 03/2024
1	Intravenous Injections 07/2021